Markedly impaired hepatic, renal, or cardiac function. Rabinowe SN, Miller KB "Danazol-induced thrombocytopenia. Danocrine, persistent amenorrhea has occasionally been reported.
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Danazol may raise the plasma levels of cyclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs. Monitoring of systemic concentrations of these drugs and appropriate dose adjustments may be needed when used concomitantly with Danazol. Store sirolimus oral liquid in the refrigerator. Do not freeze. You may notice a slight haze to the liquid after it has been refrigerated. This haze will not affect the medication, and should disappear when the medicine reaches room temperature.
The toxic effects of your carbamazepine may increase. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Laboratory monitoring of the hematologic state should be considered. Xiol X, Martinez-Lacasa J, Pons M, Marti E, Casais L "Jaundice after danazol therapy for endometriosis.
Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse. In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Amenorrhea and rapid response to painful symptoms is best achieved at this dosage level. Gradual downward titration to a dose sufficient to maintain amenorrhea may be considered depending upon patient response. For mild cases, an initial daily dose of 200 mg to 400 mg given in two divided doses is recommended and may be adjusted depending on patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules see and . It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted.
In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danazol Capsules USP are usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy. Danazol therapy. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. LOT of weight, my voice lowered, and I grew hair like crazy on my face. It's nearly 25 years later, and I still have a low voice, dark thick hair that grows all over my face, and I'm still struggling with my weight. I'm also convinced this medication had an effect on my ears, as I've had problems with vertigo since taking Danocrine. Your doctor may adjust your dose as needed and tolerated. In the treatment of hereditary angioedema, Danocrine at effective doses prevents attacks of the disease characterized by episodic edema of the abdominal viscera, extremities, face, and airway which may be disabling and, if the airway is involved, fatal. In addition, Danocrine corrects partially or completely the primary biochemical abnormality of hereditary angioedema by increasing the levels of the deficient C1 esterase inhibitor C1EI. As a result of this action the serum levels of the C4 component of the complement system are also increased. Experience with long-term therapy with danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. It should not be given intravenously. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea.
How should I take danazol? See PRECAUTIONS: Pregnancy, Teratogenic Effects. Do not use any other liquids to mix this medicine. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Use a barrier method of birth control, such as a condom or diaphragm, while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. If any of these effects persist or worsen, tell your doctor or promptly. Use danazol regularly to get the most benefit. Try not to miss any doses. Get your prescription refilled before you run out of medicine completely. What should I avoid while taking danazol Danocrine? Hosea SW, Santaella ML, Brown EJ, Berger M, Katusha K, Frank MM "Long-term therapy of hereditary angioedema with danazol. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danocrine on the pituitary-ovarian axis. If you think you have become pregnant while using the medicine, tell your doctor right away. pioglitazone
Danazol has rarely caused very serious possibly fatal blood clots such as stroke liver disease, and increased pressure on the brain benign intracranial hypertension. It may take several months for danazol to work. Do not stop using danazol without checking with your doctor. Danazol should not be administered to patients with: 1. Undiagnosed abnormal genital bleeding. 2. Markedly impaired hepatic, renal, or cardiac function. 3. Pregnancy. This information should not be used to decide whether or not to take danazol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about danazol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to danazol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using danazol. Do NOT take more medicine than prescribed unless advised to do so by your doctor.
The risk of myopathy and rhabdomyolysis is increased by concomitant administration of Danazol with statins such as simvastatin, atorvastatin and lovastatin. Caution should be exercised if used concomitantly. Consult the product labeling for statin drugs for specific information on dose restrictions in presence of Danazol. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Rosa FW "Virilization of the female fetus with maternal danazol exposure. Kahn H, Manzarbeitia C, Theise N, et al "Danazol-induced hepatocellular adenomas: A case report and review of the literature. Gastrointestinal side effects have included nausea and vomiting. Rare cases of pancreatitis have been reported. Additionally a non-hormonal method of contraception should be used during therapy. If a patient becomes pregnant while taking danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. Exposure to danazol in utero may result in androgenic effects on the female fetus; reports of clitoral hypertrophy, labial fusion, urogenital sinus defect, vaginal atresia, and ambiguous genitalia have been received. Use of Danazol in pregnancy is contraindicated. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. This information is generalized and not intended as specific medical advice. Shaw RW, Farquhar JW "Female pseudohermaphroditism associated with danazol exposure in utero. Case report. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. Tell your doctor if your condition does not improve or if it worsens. This medicine should not be given to a child younger than 13 years old. Endocrine side effects have included the inhibition of estrogen synthesis, resulting in flushing, sweating, vaginal dryness and irritation, and reduction in breast size. During administration of danazol the active ingredient contained in Danocrine endogenous testosterone synthesis and release may be inhibited through feedback inhibition of pituitary luteinizing hormone LH. Large doses of danazol may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone FSH. Danazol may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Danazol of 400 mg or more. It is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. doxycycline purchase canada
MACE in association with use of testosterone replacement therapy in men. The physician therefore should be alert to this possibility. All medicines may cause side effects, but many people have no, or minor, side effects. The information contained in the Truven Health Micromedex products as delivered by Drugs. Following an initial favorable response amenorrhea develops the dosage should be titrated to the minimum dose that suppresses disease activity. Barbieri RL "Danazol and thyroid function. Baker HW, Snedecor PA "Clinical trial of danazol for benign breast disease. Not all side effects for Danocrine may be reported. You should always consult a doctor or healthcare professional for medical advice. What happens if I miss a dose Danocrine? Ask your healthcare professional how you should dispose of any medicine you do not use. Do not receive a "live" vaccine while using sirolimus. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella MMR oral polio, typhoid, chickenpox varicella BCG Bacillus Calmette and Guérin and nasal flu vaccine.
Danocrine of 400 mg or more. It is recommended that patients receiving Danocrine be monitored for hepatic dysfunction by laboratory tests and clinical observation. Serious hepatic toxicity including cholestatic jaundice, peliosis hepatis, and hepatic adenoma have been reported. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. How should I take Danocrine danazol? If this occurs, the drug should be discontinued. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. Sirolimus may also be used for purposes not listed in this medication guide. Breastfeeding. 5. Porphyria - Danazol can induce ALA synthetase activity and hence porphyrin metabolism. 6. Androgen-dependent tumor. 7. Active thrombosis or thromboembolic disease and history of such events. 8. Hypersensitivity to Danazol. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs. Sirolimus may cause a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly. Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine Neoral, Sandimmune and a steroid medicine such as prednisone. endometrin 160 mg
What is danazol Danocrine? If you also take cyclosporine, take the sirolimus at least 4 hours after taking cyclosporine. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis. Because Danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. At first, 800 milligrams mg per day, divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Does Danocrine oral have side effects? Middleton C, McCaughan GW, Painter DM, Stephen MS, Beale M, Fraser I "Danazol and hepatic neoplasia: a case report. While using danazol, you may need blood tests at your doctor's office. Visit your doctor regularly. Danocrine in the early 90's to treat endometriosis. I was supposed to take it for about 9 months to "simulate pregnancy" by stopping my menstrual cycle long enough to "heal". I could only do it for 3 months, because the side effects were awful. Do not use Danocrine if you are pregnant. Tell your doctor if you become pregnant during treatment. Before you start taking Danocrine, you may need to have a to make sure you are not pregnant. Use an effective barrier form of birth control such as a condom or with spermicide gel or inserts. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective to prevent pregnancy during treatment. Breastfeeding is not recommended while using this drug. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Do not stop taking any medications without consulting your healthcare provider. In the treatment of endometriosis, Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases.
Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes eg mood swings, nervousness; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; unusual bleeding or bruising; vision problems; vomiting. It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects. To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. The oral liquid solution comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Avoid exposure to sunlight or tanning beds. Sirolimus may increase your risk of skin cancer. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. FDA pregnancy category C. It is not known whether sirolimus will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. Abnormalities in laboratory tests may occur during therapy with Danazol including CPK, glucose tolerance, glucagon, thyroid binding globulin, sex hormone binding globulin, other plasma proteins, lipids and lipoproteins. What should I discuss with my healthcare provider before taking danazol Danocrine? Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danocrine to receptors of gonadal steroids at target organs. In addition, Danocrine has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease. prednisone
Ask your health care provider any questions you may have about how to use danazol. Danazol is usually given for 6 to 9 months to treat fibrocystic breast disease or endometriosis. To prevent attacks of hereditary angioedema, you may need to use the medication long-term. Follow your doctor's instructions. Reversible oligospermia may occur in adult males after prolonged administration or excessive dosage. If this effect occurs, danazol can be discontinued and if restarted, a lower dosage should be utilized. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. What should I discuss with my doctor before taking sirolimus Rapamune? Do not keep outdated medicine or medicine no longer needed. Danocrine can induce ALA synthetase activity and hence porphyrin metabolism. Your doctor may occasionally change your dose to make sure you get the best results. This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, check with your doctor.
Diabetes patients - Danazol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. What happens if I overdose Rapamune? Duck SC, Katayama KP "Danazol may cause female pseudohermaphroditism. How should I take danazol Danocrine? This product's label may have been updated. generic escitalopram 500 mg
Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice yellowing of the skin or eyes. At first, 200 to 400 milligrams mg divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Additionally a non-hormonal method of contraception should be used during therapy. If a patient becomes pregnant while taking Danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. The total daily dosage of Danazol capsules for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules. A non-hormonal method of contraception is recommended when Danazol capsules are administered at this dose, since ovulation may not be suppressed. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine. Seffart G ed. "Drug Dosage in Renal Insufficiency. Webb AM, Russell J, Elstein M "Comparison of Yuzpe regimen, danazol, and mifepristone RU486 in oral postcoital contraception. Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Your birth control pills may not work as well while you are using this medicine. If you are taking Rapamune oral liquid with a disposable syringe, you may store a loaded syringe in the carrying case provided. Keep the case at room temperature and use the medicine within 24 hours. Use a disposable syringe only once and then throw it away.
The reported elimination half-life of Danazol is variable across studies. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Mercaitis PA, Peaper RE, Schwartz PA "Effect of danazol on vocal pitch: a case study. What happens if I overdose Danocrine? Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Following an initial favorable response prevention of edematous episodes attempts should be made at 1 to 3 month intervals to reduce the dosage to the minimum continuous dose that will prevent angioedema. Dosage reductions up to 50% per interval may be considered. Should angioedema recur, the daily dosage may be increased up to 200 mg. What other drugs will affect danazol? Because Danocrine may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. etok.info hydroxyzine
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Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. It is not known whether sirolimus passes into breast milk or if it could harm a nursing baby. You should not breast-feed while taking sirolimus. Disclaimer: Every effort has been made to ensure that the information provided by Multum, Truven Health Analytics, Inc. In most instances, breast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 months. Usually elimination of nodularity requires 4 to 6 months of uninterrupted therapy. Regular menstrual patterns irregular menstrual patterns and amenorrhea each occur in approximately one-third of patients treated with 100 mg of Danocrine. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses. Clinical studies have demonstrated that 50% of patients may show evidence of recurrence of symptoms within one year. In this event, treatment may be reinstated.
In order for danazol to help you, it must be taken regularly for the full time of treatment as ordered by your doctor. National Library of Medicine and Drugs. Fraser IS "Post danazol amenorrhoea.
Prolongation of prothrombin time occurs in patients stabilized on warfarin. Therapy with danazol may cause an increase in carbamazepine levels in patients taking both drugs. Danazol can cause insulin resistance when used with antidiabetic drugs. An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking Danocrine danazol? Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danazol to receptors of gonadal steroids at target organs. In addition, Danazol has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease.
Danocrine danazol is a used to treat and fibrocystic breast disease. Danocrine is also used to prevent attacks of in people with an inherited form of this disorder. The brand name Danocrine is discontinued, but versions may be available. Sirolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly. Some of the side effects that can occur with danazol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects.